The English top division declared on Friday that Everton had lost 10 points as a result of their violation of Premier League financial regulations.
Everton was referred by the league to an independent commission in March due to a purported violation of its sustainability and profitability regulations (PSRs).
Clubs risk sanctions if they lose more than £105 million ($130 million) in three years.
Everton drops to 19th place in the standings as a result of the most significant sporting penalty in the competition's history.
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"The club acknowledged it was in breach of the PSRs for the period ending season 2021/22, but the extent of the breach remained in dispute," the Premier League said in a statement.
"Following a five-day hearing last month, the commission determined that Everton FC's PSR calculation for the relevant period resulted in a loss of £124.5 million, as contended by the Premier League, which exceeded the threshold of £105 million permitted under the PSRs.
"The commission concluded that a sporting sanction in the form of a 10-point deduction should be imposed. That sanction has immediate effect."
Everton declared they would be filing an appeal in a statement stating they were "shocked and disappointed by the ruling".