Second-tier Manchester United overcame a goal deficit to defeat West Ham 3-1 in the FA Cup on Wednesday, while Tottenham was eliminated by Championship team Sheffield United. Alejandro Garnacho and Fred scored late goals for Manchester United.
Grimsby of the fourth tier embarrassed Southampton of the Premier League 2-1 in the second fifth-round matchup of the evening, and Burnley defeated Fleetwood with ten men down 1-0.
Manchester United struggled to be fluid in front of a receptive Old Trafford crowd after making six changes to the team that defeated Newcastle in the League Cup final on Sunday.
In the first half, West Ham had the better opportunities, but without the cup-tied Danny Ings, their attack appeared dull.
Michail Antonio was denied by United goalkeeper David de Gea midway through the first quarter when the West Ham forward raced down on goal, and Emerson Palmieri fired a tempting ball across the box.
At halftime, United manager Erik ten Hag substituted Scott McTominay for Casemiro, but the home team remained lethargic.
In the 54th minute, after the home defence had ceased believing the ball was out for a throw-in, Said Benrahma made them pay.
After the goal, Ten Hag substituted top scorer Marcus Rashford; Antonio had an excellent opportunity to extend West Ham's advantage, but De Gea had room for him to score.
In the 72nd minute, Casemiro headed in a Bruno Fernandes free-kick, but it was cancelled for offside.
Five minutes later, United finally equalized thanks to a corner kick from Fernandes that Nayef Aguerd headed past Alphonse Areola and into his own goal.
The host team pushed forward in pursuit of a victory while still feeling good about ending their six-year trophy drought at the weekend.
Fred scored in stoppage time to polish the score after Argentine teenager Garnacho's outstanding 90th-minute goal put United ahead.
Spurs Out -
Tottenham was eliminated from the FA Cup by Championship competition for the second year after Sheffield United defeated them 1-0 at Bramall Lane in the fifth round.
They could not recover after falling behind to Ndiaye's 79th-minute goal after starting Harry Kane on the bench.
During the match at home against League Two Grimsby, new Southampton manager Ruben Selles he made nine changes to his lineup.
Gavan Holohan's penalty gave the visitors a 1-0 lead just before halftime, and Holohan added a goal five minutes into the second half to make it 2-0.
Relegation-threatened By volleying in a corner from replacement James Ward-Prowse in the 65th minute, Duje Caleta-Car made up for giving up the second penalty and cut Southampton's lead in half.
Ten minutes later, Southampton's substitute Theo Walcott thought he had equalized, but a VAR review determined that he was offside.
The league leaders Burnley needed a goal from Connor Roberts in the 90th minute to defeat League One Fleetwood's ten men and go to the FA Cup quarterfinals for the first time in 20 years.
Manchester City advanced to the quarterfinals on Tuesday by defeating Bristol City 3-0, while 2021 champions Leicester fell to lower-division Blackburn 2-1.
In the Premier League, Fulham defeated Leeds by 2-0, while Brighton defeated Stoke by 1-0.