Real Betis was trounced by Manchester United 4-1 in the opening leg of their round of 16 Europa League matchup on Thursday, recovering from a historic thumping by Liverpool.
In Sunday's 7-0 loss at Anfield, United suffered a defeat that was their biggest ever and worst since 1931.
Erik ten Hag gave the same starting lineup in his reply and got the answers with a return to form.
"You can observe a team's response to a setback, according to "This is not the first time this season," said Ten Hag. "You have seen us restart and recover five or six times. I must give this team much credit because they have character".
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With his 26th goal of the year, Marcus Rashford gave United an early advantage. Nevertheless, Betis drew even against the odds when Ayoze Perez struck a shot into the far corner.
After the break, two of United's stars recently receiving the most scathing criticism were the key players.
Before Bruno Fernandes, who Ten Hag again selected as captain, headed into Luke Shaw's corner, Antony curled a magnificent shot into the top corner.
Ten Hag added, "Bruno was outstanding today. He set the tone for the squad right away through his play in possession, established the game's tempo, and scored a goal, so I'm pleased".
Six minutes from time, Wout Weghorst scored his second goal for United in just 15 appearances by shooting from close range.
Meanwhile, Juventus will travel to Germany with a slim advantage after defeating Freiburg 1-0 thanks to a goal from the excellent Angel di Maria.
After defeating Real Sociedad 2-0 at the Stadio Olimpico with two goals from Stephan El Shaarawy and Marash Kumbulla, Jose Mourinho's Roma are also on track to advance to the round of eight.
Six-time champions Despite being in a relegation struggle in La Liga, Sevilla is a constant threat in the Europa League. Joan Jordan and Erik Lamela's goals will give Sevilla a 2-0 first-leg advantage against Fenerbahce when they travel to Istanbul next week.
Union Berlin, a surprise package in the Bundesliga, came from three goals behind to tie Union Saint-Gilloise 3-3 in the evening game.
Shakhtar Donetsk and Feyenoord drew 1-1, while Bayer Leverkusen defeated Ferencvaros 2-0 at home.
West Ham defeated AEK Larnaca 2-0 in the UEFA Conference League thanks to two goals from Michael Antonio in the opening period.
Villarreal was kept to a 1-1 draw by Anderlecht, while Nice and Fiorentina defeated Sheriff Tiraspol and Sivasspor by scores of 1-0 each.